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Pathogenic, drug-resistant bacteria found in wastewater treatment plants

  • Pathogenic, drug-resistant bacteria found in wastewater treatment plants

About the entity

Cold Spring Harbor Laboratory
Founded in 1890, Cold Spring Harbor Laboratory has shaped contemporary biomedical research and education with programs in cancer, neuroscience, plant biology and quantitative biology.

Infections caused by drug-resistant bacteria are a global public health threat causing serious illness and even death. Strains of the bacterium Enterococcus faecium (E. faecium) are generally harmless in healthy people, but can be pathogenic in immunocompromised or severely ill patients. E. faecium strains from hospital environments have acquired resistance to commonly used antibiotics, including those used to treat serious infections, making these infections especially challenging to treat.

In a study published in Genome Research, researchers conducted a survey of 20 municipal wastewater plants in England, and isolated drug-resistant E. faecium from all sites in both untreated and treated wastewater plants except three, which use ultraviolet light disinfection. Importantly, drug-resistant E. faecium counts were significantly higher in untreated wastewater from plants that were direct recipients of hospital sewage. A genomic comparison of E. faecium isolates from wastewater and bloodstream isolates of infected patients revealed two major lineages, with ampicillin-resistant bacteria in clade A1 and A2 and vancomycin-resistant bacteria exclusive to clade A1. Further genetic analysis revealed the presence of shared antibiotic, metal, and biocide resistance genes in clade A1 isolates from bloodstream, hospital sewage, and municipal wastewater.

This study demonstrates close genetic relatedness of drug-resistant E. faecium isolates released into the environment with those that cause serious human disease. Further research is needed to determine the public health implications of exposure to healthcare- and waste-associated pathogens. Terminal ultraviolet light disinfection of wastewater is one solution that would reduce environmental contamination with drug-resistant bacteria.

Researchers from the University of Cambridge, Public Health England, Addenbrooke's Hospital, Wellcome Trust Sanger Institute, London School of Hygiene and Tropical Medicine, British Society for Antimicrobial Chemotherapy, University of Oslo, and Mahidol University contributed to this work. The study was funded by grants from the Health Innovation Challenge Fund, Wellcome Trust Research Training Fellowship, Wellcome Trust Sir Henry Postdoctoral Fellowship, and European Research Council.

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